Key result
MELD-XI score was a significant independent predictor of 30-day in-hospital mortality in patients with acute ST elevation myocardial infarction (OR 1.73; 95% CI 1.25-2.39; p<0.05).
Why the study?
The study was conducted to evaluate the MELD-XI score for predicting 30-day in-hospital mortality in patients presenting with ST elevation myocardial infarction.
Does the MELD-XI score predict 30-day in-hospital mortality in patients with acute ST elevation myocardial infarction?
Cohort (n=111)
Does the MELD-XI score predict 30-day in-hospital mortality in patients with acute ST elevation myocardial infarction?
Odds Ratio: 1.73 (95% CI 1.25–2.39)
p-value: p=<0.05
The MELD-XI score is a strong independent predictor of 30-day in-hospital mortality in patients presenting with acute STEMI.
May aid STEMI mortality risk stratification; hypothesis-generating and requires prospective validation.
Objective: We aimed to evaluate Model for End‐stage Liver Disease excluding international normalized ratio (MELD‐XI) score for prediction of 30‐day in‐hospital mortality in a cohort of patients with ST elevation myocardial infarction. Methods: The medical records of a total of 256 patients admitted with ST elevation myocardial infarction to the emergency department between January 2015 and January 2019 were retrospectively reviewed. A total of 111 patients were found eligible for the study. MELD‐XI score was analyzed and compared on the basis of survival status. Results: A total of 111 patients with a mean age of 62.5 ± 2.55 years were included in the study. In total, 81% (n = 90) of the patients were male and 19% (n = 21) were female. The mean MELD‐XI score of the patients was 10.1 ± 1.1. A total of 12 patients (12.9%) died within 30 days after hospitalization. The median MELD‐XI score of the patients who died in the hospital was significantly higher than the patients survived (11.0 (10.5–11.6) vs 9.5 (9.4–13.8); p < 0.01). However, Gensini score was not significantly different between the surviving and deceased patients (p > 0.05). MELD‐XI score was significantly correlated to left ventricular ejection fraction (r = −232, p < 0.01), and both parameters and age were significant independent predictors of in‐hospital mortality (odds ratio: 1.73, 95% confidence interval: 1.25–2.39, p < 0.05; odds ratio: 0.89, 95% confidence interval: 0.81–0.99, p < 0.05; and odds ratio: 1.07, 95% confidence interval: 0.99–1.15, p < 0.05, respectively). A MELD‐XI cut‐off point of 10 had a sensitivity of 100% and a specificity of 78.8% for in‐hospital mortality (area under receiver operating characteristics curve: 0.92, 95% confidence interval: 0.87–0.97, p < 0.05). A survival analysis based on a MELD‐XI threshold of 10 revealed that the patients in the high‐MELD‐XI group had a significantly worse in‐hospital survival (log rank test p < 0.001). Conclusion: MELD‐XI score is a useful tool for in‐hospital mortality prediction in patients referring to emergency medicine with acute ST elevation myocardial infarction.
No takes yet. Share an insight, caveat, or question.
ÇELİK et al. (2020) conducted a cohort in ST elevation myocardial infarction (n=111). MELD-XI score vs. Lower MELD-XI score was evaluated on 30-day in-hospital mortality (OR 1.73, 95% CI 1.25-2.39, p=<0.05). MELD-XI score was a significant independent predictor of 30-day in-hospital mortality in patients with acute ST elevation myocardial infarction (OR 1.73; 95% CI 1.25-2.39; p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: