Key result
Daily intake of 6 green tea polyphenol tablets significantly reduced chemotherapy-induced oxidative stress at 6 months (P=0.0463) in liver cancer patients, whereas 3 tablets did not.
Why the study?
Does 6 oral green tea polyphenol tablets per day reduce oxidative stress in liver cancer patients undergoing hepatic arterial infusion chemotherapy compared to 3 tablets per day?
Population
19 patients with inoperable hepatocellular carcinoma or metastatic liver cancer from colorectal malignancy…
Comparison
6 oral green tea polyphenol tablets per day vs 3 oral green tea polyphenol tablets per day
Design
RCT, randomly assigned into one of two oral GTP tablet groups
Follow-up
12 months
Authors
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Supports 6-tablet dosing to reduce oxidative stress during liver cancer chemotherapy; extends dose-finding data for polyphenol adjuncts.
RCT (n=19)
Open-label
Randomly assigned to 3 or 6 tablets per day
No
Does 6 oral green tea polyphenol tablets per day reduce oxidative stress in liver cancer patients undergoing hepatic arterial infusion chemotherapy compared to 3 tablets per day?
Absolute Event Rate: 376.7% vs 410.5%
p-value: p=0.0463
Daily intake of 6 green tea polyphenol tablets significantly reduces chemotherapy-induced oxidative stress in patients with inoperable liver cancer undergoing hepatic arterial infusion.
Baba et al. (2012) conducted an RCT in Hepatocellular carcinoma or metastatic liver cancer (n=19). Green tea polyphenol tablets vs. 3 tablets per day (237 mg polyphenols) was evaluated on Oxidative stress assessed by levels of derivatives of reactive oxygen metabolites (d-ROMs) at 6 months (p=0.0463). Daily intake of 6 green tea polyphenol tablets significantly reduced chemotherapy-induced oxidative stress at 6 months (P=0.0463) in liver cancer patients, whereas 3 tablets did not.
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