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August 12, 2006Journal of Biological ChemistryOpen Access

MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin

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Authors

BHBaoli HuShenyang University of TechnologyDGDaniele M. GilkesJohns Hopkins UniversityBFBilal FarooqiMercer University

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Cite This Study

Hu et al. (2006) studied this question.

synapsesocial.com/papers/6a9594ccd33c5efb307d183ehttps://doi.org/10.1074/jbc.c600147200
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p532002 · 262 citations
  2. 2Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage2005 · 180 citations
  3. 3Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-32006 · 188 citations
  4. 4Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain1996 · 2,242 citations