The biological edge in periodontal therapy: Revolutionizing periodontal treatment with autologous blood products

This review delves into the pivotal role of autologous blood products—such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and injectable platelet-rich fibrin (i-PRF)—in revolutionizing periodontal therapy by seamlessly integrating biological principles with clinical applications. These blood derivatives enhance key regenerative processes, including cellular proliferation, angiogenesis, and extracellular matrix remodelling, thereby significantly improving outcomes in soft and hard tissue healing. By synthesizing the latest research, clinical studies, and practical experiences, the review underscores the growing importance of these therapies in modern periodontics while advocating for standardized protocols and further research to maximize their clinical efficacy and long-term benefits.