May 10, 1993FEBS LettersOpen Access

Mycalolide‐B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge

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Population

Smooth muscle preparations, permeabilized smooth muscles, native actomyosin from chicken gizzard, skeletal…

Design

Preclinical

Authors

MHMasatoshi HoriMatsushita Memorial Hospital SSShinya SaitoUniversity of Shizuoka YSYutaka Z. ShinThe University of Tokyo

Discussion

Member takes

Implication

Hypothesis-generating for actomyosin-targeted probes; leaves open translation to human smooth muscle disorders.

Structured PICO

Population

Smooth muscle preparations, permeabilized smooth muscles, native actomyosin from chicken gizzard, skeletal muscle native actomyosin, and erythrocyte membranes

Intervention

Mycalolide-B (a toxin isolated from marine sponge)

Outcome

Smooth muscle contraction, superprecipitation, and Mg(2+)-ATPase activitysurrogate

Mycalolide-B acts as a specific inhibitor of actomyosin ATPase, selectively inhibiting actin-myosin interaction in muscle preparations.

Cite This Study

Hori et al. (1993) studied this question.

synapsesocial.com/papers/6a959bb2ed9545b357b2c06e https://doi.org/10.1016/0014-5793(93)81557-g

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Mycalolide‐B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mycalolide‐B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider