Key result
Lithium therapy, even within therapeutic ranges, can unmask Brugada syndrome in bipolar patients, with electrocardiographic abnormality severity corresponding to lithium levels.
Why the study?
Does lithium therapy unmask Brugada syndrome in bipolar patients?
Population
1 bipolar patient with Brugada syndrome
Design
Case_report
Authors
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May warrant ECG surveillance in lithium-treated bipolar patients with suggestive features; hypothesis-generating and requires prospective validation before practice change.
Does lithium therapy unmask Brugada syndrome in bipolar patients?
Lithium can unmask Brugada syndrome even at therapeutic levels, highlighting a potential arrhythmia risk in a genetically susceptible subpopulation of bipolar patients.
Crawford et al. (2014) studied this question. Lithium therapy, even within therapeutic ranges, can unmask Brugada syndrome in bipolar patients, with electrocardiographic abnormality severity corresponding to lithium levels.
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