Key result
Myofibroblasts in the infarct border zone of mouse hearts are electrically coupled to adjacent ventricular myocytes, exhibiting slower voltage transient kinetics and low connexin43 expression.
Population
Transgenic mice with cardiomyocyte-restricted or myofibroblast-specific expression of a fluorescent reporter…
Design
Preclinical
Follow-up
7-10 days
Authors
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May influence post-MI border zone conduction in mice; leaves open relevance to human ventricular arrhythmias.
Myofibroblasts electrically couple to cardiomyocytes in the infarct border zone, but their slower voltage kinetics and low connexin expression suggest low electrical conductivity across these heterocellular junctions.
Rubart et al. (2017) studied Myocardial infarction. Myocardial infarction (permanent coronary artery ligation) vs. Remote, uninjured myocardium was evaluated on Transmembrane voltage changes and connexin expression at heterocellular junctions. Myofibroblasts in the infarct border zone of mouse hearts are electrically coupled to adjacent ventricular myocytes, exhibiting slower voltage transient kinetics and low connexin43 expression.
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