Key result
Hepatitis A virus monoinfections were associated with significant overexpression of IL-4, IL-12, IL-13, and interferon-gamma, whereas hepatitis E virus infections showed limited cytokine secretion.
Observational
Cytokine profiles can help discriminate between HAV/HEV coinfections and monoinfections in pediatric patients with acute hepatitis.
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Cytokine profiles may aid discrimination of pediatric HAV versus HEV monoinfections; hypothesis-generating and requires prospective validation before clinical use.
The frequency of hepatitis A virus and hepatitis E virus infections and their cytokine profiles were analyzed in Mexican pediatric patients with acute hepatitis. A high frequency of coinfections was found. Significant overexpression of interleukin (IL)-4, IL-12, IL-13 and interferon-gamma during hepatitis A virus monoinfections and limited secretion of cytokines in hepatitis E virus infections were observed.
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Realpe et al. (2017) conducted an observational in Acute hepatitis. Hepatitis A virus and Hepatitis E virus infections vs. Monoinfections vs Coinfections was evaluated on Cytokine profiles (IL-4, IL-12, IL-13, and interferon-gamma). Hepatitis A virus monoinfections were associated with significant overexpression of IL-4, IL-12, IL-13, and interferon-gamma, whereas hepatitis E virus infections showed limited cytokine secretion.
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