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Desoxycorticosterone reversibly inhibits the pulsation of mouse or chick heart fragments in vitro.
DOC reversibly inhibits the pulsation of mouse or chick heart fragments in vitro. The inhibition can be removed by serum but not by cortisone, and is more effective in the absence of potassium. DOC and cortisone have no influence upon potassium inhibition of the heart. Epinephrine will almost completely counteract potassium inhibition but revives only a few DOC-poisoned fragments.
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Ivor Cornman (1950) studied this question.
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