Why the study?
Does doxorubicin suppress ouabain-induced or infarct-induced ventricular tachycardia in canine models?
Does doxorubicin suppress ouabain-induced or infarct-induced ventricular tachycardia in canine models?
Doxorubicin selectively suppresses triggered arrhythmias caused by delayed afterdepolarizations, suggesting utility as a tool to discriminate arrhythmogenic mechanisms in intact animals.
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Doxorubicin may help discriminate triggered from other ventricular arrhythmias in animal models; leaves open any clinical translation or mechanistic utility in patients.
Marec et al. (1986) studied this question.
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