What does this research mean for the field?

Specific pacing protocols, including overdrive pacing and premature extra stimuli, can predictably induce and terminate ouabain-induced delayed afterdepolarizations and triggered activity, providing a quantitative profile that may help differentiate this arrhythmogenic mechanism from others. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1984Circulation

Induction and termination of triggered activity by pacing in isolated canine Purkinje fibers.

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Population

Isolated canine Purkinje fibers superfused with 2 X 10M ouabain until delayed afterdepolarizations occurred…

Design

Preclinical

Authors

JMJeffrey P. MoakUniversity of California, Irvine MRMichael R. RosenUniversity of Insubria

Discussion

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Implication

Pacing protocols differentiate triggered activity in canine models; leaves open relevance to human arrhythmias.

Structured PICO

Population

Isolated canine Purkinje fibers superfused with 2 X 10(7)M ouabain until delayed afterdepolarizations occurred and attained an amplitude of 5 mV at a paced cycle length of 500 msec

Intervention

Pacing protocols including overdrive pacing, single (S2) premature beats, and double (S2S3) premature beats

Outcome

Induction and termination of triggered activity and sustained rhythmic activitysurrogate

Specific pacing protocols can predictably induce or terminate ouabain-induced triggered activity in canine Purkinje fibers, providing a quantitative basis to differentiate this arrhythmogenic mechanism from others.

Cite This Study

Moak et al. (1984) studied this question.

synapsesocial.com/papers/6a1bde74ea84844e355f16f8 https://doi.org/10.1161/01.cir.69.1.149

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Induction and termination of triggered activity by pacing in isolated canine Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Induction and termination of triggered activity by pacing in isolated canine Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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