Key result
Local endocardial infusion of ouabain induced sustained monomorphic ventricular tachycardia in all 15 dogs, which was completely eliminated by local perfusion of verapamil.
Local endocardial infusion of ouabain in a canine model reliably induces focal triggered ventricular tachycardia that is suppressed by verapamil, providing an in vivo model for studying triggered arrhythmias.
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Enables focal in vivo study of triggered activity; hypothesis-generating and should not yet change practice.
Furukawa et al. (1990) studied Ventricular arrhythmias (n=15). Ouabain infusion vs. Baseline / reference site was evaluated on Induction of sustained monomorphic ventricular tachycardia (VT). Local endocardial infusion of ouabain induced sustained monomorphic ventricular tachycardia in all 15 dogs, which was completely eliminated by local perfusion of verapamil.
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