What question did this study set out to answer?

This research aims to evaluate the effect of transient heart rate increases on ventricular pacemaker activity during ouabain administration in dogs.

June 1, 1970Circulation Research

Acceleration of Ventricular Pacemakers by Transient Increases in Heart Rate in Dogs during Ouabain Administration

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Why the study?

Do transient increases in heart rate accelerate ventricular pacemakers during ouabain administration in dogs?

Population

15 anesthetized, vagotomized dogs

Comparison

30-second periods of atrial pacing to… vs Baseline ventricular automaticity assessed by…

Design

Preclinical

Authors

SWStephen M. WittenbergUniversity of Bern FSF StreuliUniversity of Zurich FKFrancis J. KlockeCardiac Imaging

Discussion

Member takes

Implication

Transient rate increases may accelerate ventricular pacemakers during ouabain in dogs; leaves open human relevance and arrhythmia risk.

Key Points

This research aims to evaluate the effect of transient heart rate increases on ventricular pacemaker activity during ouabain administration in dogs.
Fifteen anesthetized, vagotomized dogs were studied during ouabain infusion.
Vagal stimulation assessed baseline ventricular automaticity, while 30-second atrial pacing evaluated ventricular pacemaker response to rate increments.
Patients received an average dose of 45 ± 3 µg/kg of ouabain.
After vagal stimulation, 14 out of 15 animals displayed an automatic ventricular focus.
Ventricular acceleration averaged 59 ± 4% of the increments in atrial pacing rate.
Postpacing depression occurred at higher driving rates before rapid ventricular focus emergence.

Structured PICO

Do transient increases in heart rate accelerate ventricular pacemakers during ouabain administration in dogs?

Population

15 anesthetized, vagotomized dogs

Intervention

30-second periods of atrial pacing to transiently increase heart rate during ouabain infusion or after recovery from ouabain-induced ventricular tachycardia

Comparator

Baseline ventricular automaticity assessed by vagal stimulation

Outcome

Response of ventricular pacemakers (ventricular acceleration)surrogate

Transient increases in heart rate may accelerate rather than depress ventricular pacemakers during digitalization in a canine model.

Cite This Study

Wittenberg et al. (1970) studied this question.

synapsesocial.com/papers/6a716522febe604dd70a10ae https://doi.org/10.1161/01.res.26.6.705

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Acceleration of Ventricular Pacemakers by Transient Increases in Heart Rate in Dogs during Ouabain Administration

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Acceleration of Ventricular Pacemakers by Transient Increases in Heart Rate in Dogs during Ouabain Administration

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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