Key result
Digitalis-induced unifocal ventricular tachycardia originates below the His bundle from Purkinje tissue supplying the left ventricle, whose automaticity is preferentially enhanced by ouabain.
Population
Pentobarbital-anesthetized open-chest dogs and isolated right and left ventricular Purkinje fiber preparations
Design
Preclinical
Authors
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No immediate change to digitalis use in patients; leaves open whether left ventricular Purkinje automaticity drives clinical toxicity.
This preclinical study demonstrates that digitalis-induced ventricular tachycardia originates from left ventricular Purkinje fibers, providing mechanistic insight into digitalis toxicity.
Kastor et al. (1972) studied Digitalis-induced unifocal ventricular tachycardia (n=9). Ouabain and acetylstrophanthidin was evaluated on Origin of ventricular ectopic beats. Digitalis-induced unifocal ventricular tachycardia originates below the His bundle from Purkinje tissue supplying the left ventricle, whose automaticity is preferentially enhanced by ouabain.
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