Why the study?
Does pacing affect triggered activity induced by early afterdepolarizations in isolated canine Purkinje fibers?
Population
Isolated canine Purkinje fibers
Design
Preclinical
Key result
Cesium induced early afterdepolarizations at low or high membrane potentials in isolated canine Purkinje fibers, with the latter inducing triggered activity that responded to overdrive pacing.
Authors
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Overdrive pacing suppresses EAD-triggered activity in canine Purkinje fibers; leaves open relevance to human arrhythmia mechanisms.
Does pacing affect triggered activity induced by early afterdepolarizations in isolated canine Purkinje fibers?
Triggered rhythms induced by early afterdepolarizations in canine Purkinje fibers respond to overdrive pacing and extrastimuli similarly to abnormal automatic mechanisms.
Damiano et al. (1984) studied Early afterdepolarizations and triggered arrhythmias. Cesium chloride and pacing protocol was evaluated on Response of early afterdepolarizations and triggered activity to sustained drive and extrastimuli. Cesium induced early afterdepolarizations at low or high membrane potentials in isolated canine Purkinje fibers, with the latter inducing triggered activity that responded to overdrive pacing.