February 1, 1993Journal of Cardiovascular Electrophysiology
Drug‐Induced Afterdepolarizations and Triggered Activity Occur in a Discrete Subpopulation of Ventricular Muscle Cells (M Cells) in the Canine Heart:
Population
Canine ventricle tissue preparations
Comparison
Therapeutic levels of quinidine and toxic levels… vs Comparison across different myocardial cell types
Design
Preclinical
Authors
Discussion
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Implication
M cells and Purkinje fibers may drive drug-induced triggered arrhythmias; leaves open clinical translation from canine models.
Structured PICO
P
Population
Canine ventricle tissue preparations (epicardial, M region, endocardial, deep subendocardial, and Purkinje fibers)
I
Intervention
Therapeutic levels of quinidine and toxic levels of digitalis (acetylstrophanthidin)
C
Comparator
Comparison across different myocardial cell types (epicardial, endocardial, deep subendocardial)
O
Outcome
Occurrence of early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and triggered activitysurrogate
Drug-induced afterdepolarizations and triggered activity are preferentially induced in a discrete subpopulation of cells in the deep subepicardial (M cell) region and Purkinje system of the canine ventricle.
Cite This Study
Sicouri et al. (1993) studied this question.