July 1, 1988Circulation
Delayed afterdepolarizations elicited in vivo by left stellate ganglion stimulation.
Key result
Left stellate ganglion stimulation induced delayed afterdepolarizations in 71% of anesthetized cats and significantly reduced action potential duration at 50% repolarization (P<0.005).
Why the study?
Does left stellate ganglion stimulation or calcium/digitalis administration induce delayed afterdepolarizations in vivo in anesthetized cats?
Population
Anesthetized cats (n=31)
Comparison
Left stellate ganglion stimulation for 45… vs Baseline (pre-intervention)
Design
Preclinical
Authors
Discussion
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Implication
Supports sympathetic-triggered ventricular arrhythmogenesis; leaves open human translation pending prospective studies.
Structured PICO
Does left stellate ganglion stimulation or calcium/digitalis administration induce delayed afterdepolarizations in vivo in anesthetized cats?
P
Population
Anesthetized cats evaluated for delayed afterdepolarizations during left stellate ganglion stimulation or calcium and digitalis administration.
I
Intervention
Left stellate ganglion stimulation for 45 seconds (n=14); calcium gluconate (0.5 g) and G-strophanthin (100 micrograms) administration (n=11); atrial pacing and graded aortic constriction (n=6)
C
Comparator
Baseline (pre-intervention)
O
Outcome
Induction of delayed afterdepolarizations (DAD) and changes in action potential duration (APD50 and APD90)surrogate
In vivo activation of cardiac sympathetic nerves or administration of calcium and digitalis can induce delayed afterdepolarizations, suggesting triggered activity as a likely mechanism for adrenergic-mediated ventricular arrhythmogenesis.
Cite This Study
Priori et al. (1988) studied this question. Left stellate ganglion stimulation vs. Baseline was evaluated on Induction of delayed afterdepolarizations (DAD). Left stellate ganglion stimulation induced delayed afterdepolarizations in 71% of anesthetized cats and significantly reduced action potential duration at 50% repolarization (P<0.005).