Key result
Afterdepolarizations, including delayed and early afterdepolarizations, initiate clinical arrhythmias by depolarizing membrane potential to the threshold for triggering action potentials.
Design
Review
Authors
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Confirms afterdepolarizations as arrhythmia triggers; leaves open targeted therapies for torsades de pointes.
This review outlines the cellular mechanisms by which delayed and early afterdepolarizations trigger clinical arrhythmias such as torsade de pointes.
Andrew L. Wit (2018) conducted a review in Clinical arrhythmias. Afterdepolarizations, including delayed and early afterdepolarizations, initiate clinical arrhythmias by depolarizing membrane potential to the threshold for triggering action potentials.
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