July 1, 1999AJP Heart and Circulatory Physiology
Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure
Population
Midmyocardial ventricular cells isolated from dogs with pacing-induced heart failure and nonpaced controls
Comparison
Pacing-induced heart failure model, evaluated… vs Cells from nonpaced control dogs
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May promote arrhythmogenesis in HF; leaves open translation to human therapies or sudden-death prevention.
Structured PICO
P
Population
Midmyocardial ventricular cells isolated from dogs with pacing-induced heart failure (n=25) and nonpaced controls (n=27)
I
Intervention
Pacing-induced heart failure model, evaluated under basal conditions and after lowering external K+ to 2 mM and exposing to cesium 3 mM
C
Comparator
Cells from nonpaced control dogs
O
Outcome
Action potential duration, early afterdepolarizations (EAD), and spontaneous depolarizations (SD)surrogate
Cardiomyopathic canine ventricular cells are intrinsically predisposed to early afterdepolarizations and spontaneous depolarizations, suggesting a cellular mechanism for sudden death in heart failure.
Cite This Study
Nuss et al. (1999) studied this question.