November 1, 2002Annals of the New York Academy of Sciences
Role of the Na/Ca Exchanger in Arrhythmias in Compensated Hypertrophy
Population
Dogs with chronic complete atrioventricular block (6-8 weeks) and compensated biventricular hypertrophy
Design
Preclinical
Follow-up
6-8 weeks
Authors
Discussion
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Member takes
Implication
May link compensated hypertrophy to sudden death risk; leaves open whether SR Ca2+ or NCX modulation alters outcomes in patients.
Structured PICO
P
Population
Dogs with chronic complete atrioventricular block (6-8 weeks) and compensated biventricular hypertrophy
I
Intervention
Pacing protocols and/or administration of ouabain
O
Outcome
Arrhythmogenic delayed afterdepolarizations (DADs) and ectopic beatssurrogate
In compensated hypertrophy, increased sarcoplasmic reticulum calcium load and Na/Ca exchanger activity may drive arrhythmogenesis and sudden death prior to the onset of overt heart failure.
Cite This Study
Sipido et al. (2002) studied this question.