Population
Dog model of cardiac hypertrophy and arrhythmias and general discussion of cardiovascular disease
Design
Review
Authors
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Requires caution in Na/Ca exchanger-targeted antiarrhythmics; leaves open optimal Ca2+ balance strategies for prospective trials.
The review highlights the complex role of the Na/Ca exchanger in ventricular arrhythmias, emphasizing its contribution to afterdepolarizations and the need to carefully consider Ca2+ balance when developing targeted drugs.
SIPIDO et al. (2007) studied this question.
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