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October 1, 1993Cardiovascular ResearchOpen Access

Sodium/calcium exchanger in heart muscle: molecular biology, cellular function, and its special role in excitation-contraction coupling

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Population

Heart muscle, isolated single cells, and cloned Na/Ca exchanger from diverse mammalian species

Design

Review

Key result

The Na/Ca exchanger plays a central role in excitation-contraction coupling, operating as a two-step sequential transporter with tissue-specific functions modulated by the intracellular loop.

Authors

DSDan H. SchulzePKPaulo KofujiRHR. W. Hadley

Discussion

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Overview

No immediate clinical implications; leaves open targeted research on tissue-specific Na/Ca exchanger modulation.

Structured PICO

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Population
Heart muscle, isolated single cells, and cloned Na/Ca exchanger from diverse mammalian species

The Na/Ca exchanger plays a central role in cardiac excitation-contraction coupling and exhibits tissue-specific functions modulated by its intracellular loop.

Cite This Study

Schulze et al. (1993) reported a review. Na/Ca exchanger was evaluated. The Na/Ca exchanger plays a central role in excitation-contraction coupling, operating as a two-step sequential transporter with tissue-specific functions modulated by the intracellular loop.

synapsesocial.com/papers/6a23012ace88d8ac62d274bahttps://doi.org/10.1093/cvr/27.10.1726
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