January 1, 2002Journal of Cardiovascular Electrophysiology
Calcium Cycling in Heart Failure: The Arrhythmia Connection
Population
Nonischemic heart failure
Design
Review
Authors
Discussion
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Implication
Emphasizes calcium dysregulation in HF arrhythmias; leaves open targeted Na/Ca exchanger therapies.
Key Points
- To investigate the role of calcium cycling in triggering arrhythmias in nonischemic heart failure.
- Analyzed the mechanisms leading to delayed afterdepolarizations in heart failure.
- Evaluated the effects of the up-regulated Na/Ca exchanger and decreased I(K1) on arrhythmias.
- Assessed cellular calcium handling in the failing heart.
- Increased Na/Ca exchanger activity is linked to higher rates of triggered arrhythmias.
- Delayed afterdepolarizations contribute significantly to arrhythmia risk in heart failure.
- Altered calcium handling is associated with worsened mechanical function in the heart.
Structured PICO
P
Population
Nonischemic heart failure
Highlights the critical role of altered cellular calcium handling and the Na/Ca exchanger in the pathogenesis of ventricular tachycardia and mechanical dysfunction in nonischemic heart failure.
Cite This Study
Pogwizd et al. (2002) studied this question.