Key result
Structural and electrophysiological compensations in HF progression increase arrhythmogenesis and impair SR Ca2+ release.
Design
Review
Authors
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May inform arrhythmia risk assessment in HF progression; leaves open optimal targeting of compensatory mechanisms.
Compensatory structural and electrophysiological changes in the failing heart ultimately increase arrhythmogenesis and compromise cellular calcium handling.
Kenneth T. MacLeod (2022) conducted a review in Heart failure. During the progression towards heart failure, structural and electrophysiological compensations occur at the expense of increasing arrhythmogenesis and decreasing the efficiency of SR Ca2+ release.
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