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November 1, 1983Circulation ResearchOpen Access

The effects of adriamycin on normal and ouabain-toxic canine Purkinje and ventricular muscle fibers.

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Key result

Adriamycin (50 microM) reversibly reduced the amplitude of ouabain-induced delayed afterdepolarizations in canine Purkinje fibers by 78% (P<0.01).

Population

Canine Purkinje and ventricular muscle fibers (normal and ouabain-toxic)

Design

Preclinical

Authors

OBOfer BinahTechnion – Israel Institute of TechnologyICIra S. CohenThomas Jefferson UniversityMRM R RosenColumbia University

Discussion

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Implication

Hypothesis-generating for adriamycin in triggered arrhythmias; requires in vivo validation before any clinical consideration.

Structured PICO

P
Population
Canine Purkinje and ventricular muscle fibers studied using standard microelectrode techniques to assess the effects of adriamycin on ouabain-induced toxicity.
I
Intervention
Adriamycin 10-200 microM
O
Outcome
Transmembrane potential, action potential duration, delayed afterdepolarizations, and aftercontractionssurrogate

Main Result

p-value: p=<0.01

Adriamycin reversibly depresses ouabain-induced delayed afterdepolarizations and aftercontractions in canine cardiac fibers, suggesting potential mechanisms involving transient inward current or sodium-calcium exchange.

Limitations

  • Whether the mechanism is direct inhibition of transient inward current or indirect reduction via reduced sodium-calcium exchange activity requires further experimentation.
  • Mechanism of action (direct vs indirect) requires further experimentation

Cite This Study

Binah et al. (1983) studied Ouabain-toxicity in cardiac fibers (n=9). Adriamycin vs. Baseline/Control was evaluated on Ouabain-induced delayed afterdepolarization amplitude (p=<0.01). Adriamycin (50 microM) reversibly reduced the amplitude of ouabain-induced delayed afterdepolarizations in canine Purkinje fibers by 78% (P<0.01).

synapsesocial.com/papers/6a22f292816bec650460d65dhttps://doi.org/10.1161/01.res.53.5.655
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A clinicopathologic analysis of adriamycin cardiotoxicity1973 · 1,566 citations
  2. 2Initiation of Sustained Rhythmic Activity by Single Propagated Action Potentials in Canine Cardiac Purkinje Fibers Exposed to Sodium-Free Solution or to Ouabain1974 · 113 citations
  3. 3Effect of Verapamil on the Normal Action Potential and on a Calcium Dependent Slow Response of Canine Cardiac Purkinje Fibers1974 · 226 citations
  4. 4Effect of Calcium on Acetylstrophanthidin-Induced Transient Depolarizations in Canine Purkinje Tissue1973 · 195 citations
  5. 5Effect of tetrodotoxin on action potentials of the conducting system in the dog heart1979 · 241 citations