March 1, 1986AJP Heart and Circulatory Physiology

Adriamycin stimulates low-affinity Ca2+ binding and lipid peroxidation but depresses myocardial function

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Population

Rat myocardium (sarcolemmal vesicles isolated from ventricles and isolated papillary muscle)

Design

Preclinical

Authors

PSPawan K. Singal GPGrant N. Pierce

Discussion

Member takes

Overview

Highlights adriamycin cardiotoxicity mechanisms in rats; leaves open translation to human dosing or prevention.

Structured PICO

Population

Rat myocardium (sarcolemmal vesicles isolated from ventricles and isolated papillary muscle)

Intervention

Adriamycin at concentrations of 10(-9) to 10(-3) M

Outcome

Sarcolemmal ATP-independent Ca2+ binding, contractility, ultrastructure, energy stores (ATP and creatine phosphate), and lipid peroxide activitysurrogate

In vitro exposure of rat myocardium to adriamycin causes depressed contractility, energy depletion, and lipid peroxidation, providing mechanistic insight into adriamycin-induced cardiotoxicity.

Cite This Study

Singal et al. (1986) studied this question.

synapsesocial.com/papers/6a237397fdd7df511fd312b1 https://doi.org/10.1152/ajpheart.1986.250.3.h419

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March 1, 1986AJP Heart and Circulatory Physiology

Adriamycin stimulates low-affinity Ca2+ binding and lipid peroxidation but depresses myocardial function

View Full Paper

Ask AI

Bookmark

Population

Rat myocardium (sarcolemmal vesicles isolated from ventricles and isolated papillary muscle)

Design

Preclinical

Authors

PSPawan K. Singal GPGrant N. Pierce

Discussion

Member takes

Overview

Highlights adriamycin cardiotoxicity mechanisms in rats; leaves open translation to human dosing or prevention.

Structured PICO

Population

Rat myocardium (sarcolemmal vesicles isolated from ventricles and isolated papillary muscle)

Intervention

Adriamycin at concentrations of 10(-9) to 10(-3) M

Outcome

Sarcolemmal ATP-independent Ca2+ binding, contractility, ultrastructure, energy stores (ATP and creatine phosphate), and lipid peroxide activitysurrogate

In vitro exposure of rat myocardium to adriamycin causes depressed contractility, energy depletion, and lipid peroxidation, providing mechanistic insight into adriamycin-induced cardiotoxicity.

Cite This Study

Singal et al. (1986) studied this question.

synapsesocial.com/papers/6a237397fdd7df511fd312b1 https://doi.org/10.1152/ajpheart.1986.250.3.h419

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