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October 1, 1990Cardiovascular Research

Adriamycin cardiomyopathy in the rabbit: alterations in contractile proteins and myocyte function

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Why the study?

Does adriamycin alter contractile proteins and myocyte function in a rabbit model?

Population

24 white male New Zealand rabbits treated with adriamycin, 29 untreated controls. An additional 6 rabbits…

Comparison

Adriamycin twice a week for eight weeks… vs Untreated controls.

Design

Preclinical

Follow-up

10 weeks (8 weeks treatment + 2 weeks recovery)

Authors

SJSusan JonesGriffith UniversityMKM S KirbyBristol-Myers Squibb (United States)SHSiân E. HardingHeart Failure & Transplant

Discussion

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Member takes

Overview

Rabbit data link adriamycin to myosin loss and reduced contractility; hypothesis-generating for human anthracycline cardiomyopathy mechanisms.

Structured PICO

Does adriamycin alter contractile proteins and myocyte function in a rabbit model?

P
Population
24 white male New Zealand rabbits treated with adriamycin, 29 untreated controls. An additional 6 rabbits treated with isoprenaline and 5 controls.
I
Intervention
Adriamycin (1 mg.kg-1) twice a week for eight weeks, followed by two weeks of recovery.
C
Comparator
Untreated controls.
O
Outcome
Contractile responses of single isolated cardiac myocytes to increasing calcium and isoprenaline, oxygen consumption, creatine kinase, myosin isoforms, and degree of fibrosis.surrogate

Adriamycin-induced heart failure in rabbits is associated with decreased myocyte contractility and low myosin content, without beta-adrenoceptor desensitization.

Cite This Study

Jones et al. (1990) studied this question.

synapsesocial.com/papers/6a90e43ff61bbdbd5ac1a655https://doi.org/10.1093/cvr/24.10.834
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abnormal β-Adrenergic Transmembrane Signaling in Rabbits With Adriamycin-Induced Cardiomyopathy1997 · 21 citations
  2. 2Adriamycin cardiomyopathy in the rabbit: an animal model of low output cardiac failure with activation of vasoconstrictor mechanisms1985 · 89 citations
  3. 3An experimental model of chronic cardiac failure using adriamycin in the rabbit: central haemodynamics and regional blood flow1987 · 29 citations
  4. 4Function of Myocardial Mitochondria in the Adriamycin-Induced Cardiomyopathy of Rabbits21976 · 30 citations
  5. 5Protein synthesis is increased in heart failure induced by low dose adriamycin in rabbits1989 · 2 citations