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Does adriamycin alter contractile proteins and myocyte function in a rabbit model?
Does adriamycin alter contractile proteins and myocyte function in a rabbit model?
Adriamycin-induced heart failure in rabbits is associated with decreased myocyte contractility and low myosin content, without beta-adrenoceptor desensitization.
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Rabbit data link adriamycin to myosin loss and reduced contractility; hypothesis-generating for human anthracycline cardiomyopathy mechanisms.
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Jones et al. (1990) studied this question.
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