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Despite causing prominent ultrastructural mitochondrial lesions, adriamycin did not alter respiratory control rates or ADP:O ratios in isolated rabbit myocardial mitochondria.
Ultrastructural examination of the myocardia of New Zealand White rabbits showed a progressive cardiomyopathy with prominent mitochondrial lesions after 56 days of increased doses of adriamycin. During all phases of study, similar respiratory control rates and ADP:O ratios were found in myocardial mitochondria isolated from adriamycin-treated and control rabbits.
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Bier et al. (1976) studied this question.
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