What is the clinical evidence from this study?

Study design: Other. Population: Adriamycin-induced myocardiopathy. Intervention: Adriamycin. Primary outcome: Ultrastructural alterations of atrial myocardium.

February 1, 1978Tumori Journal

Ultrastructural Alterations of Atrial Myocardium Induced by Adriamycin in Chronically Treated Animals

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Key result

Chronic adriamycin injection in rabbits and mice induced diffuse ultrastructural lesions in atrial myocells and decreased specific atrial granules.

Population

rabbits and mice

Design

Preclinical

Authors

GLGiorgio Lambertenghi‐DeliliersUniversity of Milan PZPaola ZanonUniversity of Padua EPE PozzoliPoliclinico Universitario di Catania

Discussion

Member takes

Implication

May extend adriamycin cardiotoxicity to atria in animals; leaves open human relevance.

Structured PICO

Population

Rabbits and mice injected with adriamycin to study chronic toxicity effects on atrial myocardium.

Intervention

Adriamycin injected according to schedules of chronic toxicity

Outcome

Ultrastructural lesions of mitochondria, sarcoplasmic reticulum, myofibrillar bundles, and specific atrial granules in atrial myocellssurrogate

Chronic adriamycin administration induces significant ultrastructural damage to atrial myocardium in animal models, extending the understanding of its cardiotoxic effects beyond the ventricles.

Limitations

Lack of information about the contents and exact function of atrial granules prevents concluding their decrease has pathogenetic significance.
Lack of information about the contents and exact function of atrial granules prevents concluding if their decrease has pathogenetic significance in adriamycin-induced myocardiopathy

Cite This Study

Lambertenghi‐Deliliers et al. (1978) studied Adriamycin-induced myocardiopathy. Adriamycin was evaluated on Ultrastructural alterations of atrial myocardium. Chronic adriamycin injection in rabbits and mice induced diffuse ultrastructural lesions in atrial myocells and decreased specific atrial granules.

synapsesocial.com/papers/6a9e8df69b96c7cdcc944a2a https://doi.org/10.1177/030089167806400102

Topics

Myocarditis

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Ultrastructural Alterations of Atrial Myocardium Induced by Adriamycin in Chronically Treated Animals

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Ultrastructural Alterations of Atrial Myocardium Induced by Adriamycin in Chronically Treated Animals

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider