Key result
Myocardium from male mice treated with a single 20 mg/kg dose of adriamycin was prepared for electron microscopy to evaluate cytopathologic effects compared to saline controls.
Why the study?
Does a single intraperitoneal dose of adriamycin induce cytopathologic changes in murine cardiac tissue compared to physiologic saline?
Does a single intraperitoneal dose of adriamycin induce cytopathologic changes in murine cardiac tissue compared to physiologic saline?
This preclinical study aims to characterize the ultrastructural cytopathologic effects of adriamycin on murine myocardium to better understand its cardiotoxicity.
Answers are grounded in this paper and cite their sources.
This murine model preparation supports hypothesis generation on adriamycin cardiotoxicity; leaves open translation to clinical monitoring or dosing.
Adriamycin and daunomycin are structurally related antibiotics used in the clinical management of neoplastic diseases. However, adriamycin has exhibited a higher therapeutic index against a wide variety of tumors and thus is currently of greater clinical interest. Like daunomycin, adriamycin produces a delayed, irreversible, lethal cardiac toxicity. The present study was initiated to compare the cytopathology of cardiac tissue from adriamycin-treated mice with previous ultrastructural observations of myocardium from daunomycin-treated rodents. Four to eight days after drug administration, myocardium from the ventricles of 8 moribund BDF 1 male mice which received a single intraperitoneal dose of adriamycin (20 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde or Karnovsky's glutaraldehyde-paraformaldehyde and prepared for electron microscopy.
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Liss et al. (1973) studied cardiac toxicity. Adriamycin vs. physiologic saline was evaluated on cytopathology of cardiac tissue. Myocardium from male mice treated with a single 20 mg/kg dose of adriamycin was prepared for electron microscopy to evaluate cytopathologic effects compared to saline controls.
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