September 1, 1983Circulation Research

Compartmentalization of adriamycin and daunomycin in cultured chick cardiac myocytes. Effects on synthesis of contractile and cytoplasmic proteins.

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Population

Cultured embryonic chick heart cells (myocytes)

Design

Preclinical

Follow-up

up to 6 hours

Authors

WLWilliam LewisTulane University MGM Galizi SPSaul PuszkinAmerican Red Cross

Discussion

Member takes

Implication

Hypothesis-generating for anthracycline cardiotoxicity mechanisms; leaves open in vivo translation and verapamil effects.

Structured PICO

Population

Cultured embryonic chick heart cells (myocytes)

Intervention

Adriamycin and daunomycin (micromolar concentrations, e.g., 2 microM)

Outcome

Drug uptake, compartmentalization into subcellular fractions, and effects on the synthesis of cytoplasmic and cytoskeletal proteinssurrogate

Anthracyclines are rapidly incorporated into cardiac myocytes and inhibit cytoplasmic protein synthesis, providing insight into early mechanisms of cardiotoxicity.

Cite This Study

Lewis et al. (1983) studied this question.

synapsesocial.com/papers/6a8383f49492d09e1bb402a4 https://doi.org/10.1161/01.res.53.3.352

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Compartmentalization of adriamycin and daunomycin in cultured chick cardiac myocytes. Effects on synthesis of contractile and cytoplasmic proteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Compartmentalization of adriamycin and daunomycin in cultured chick cardiac myocytes. Effects on synthesis of contractile and cytoplasmic proteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider