April 1, 1982Circulation ResearchOpen Access

Interaction of adriamycin in vitro with cardiac myofibrillar proteins.

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Population

Purified canine heart actin and alpha-actinin (in vitro model)

Comparison

Doxorubicin (Adriamycin) vs F-actin controls (no doxorubicin)

Design

Preclinical

Authors

WLWilliam LewisTulane University JKJerome KleinermanBrigham and Women's Hospital SPSaul PuszkinAmerican Red Cross

Discussion

Member takes

Implication

Suggests direct myofibrillar disruption may underlie doxorubicin cardiotoxicity; hypothesis-generating, needs in vivo confirmation before clinical relevance.

Structured PICO

Population

Purified canine heart actin and alpha-actinin (in vitro model)

Intervention

Doxorubicin (Adriamycin)

Comparator

F-actin controls (no doxorubicin)

Outcome

Binding to cardiac muscle contractile proteins and effects on actin polymerization, filament formation, and myosin-ATPase stimulationsurrogate

Doxorubicin directly alters the biophysical and biochemical properties of heart myofibril proteins in vitro, providing insight into potential mechanisms of anthracycline cardiotoxicity.

Cite This Study

Lewis et al. (1982) studied this question.

synapsesocial.com/papers/6a79841bb008f0cadf32226e https://doi.org/10.1161/01.res.50.4.547

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Implication

Suggests direct myofibrillar disruption may underlie doxorubicin cardiotoxicity; hypothesis-generating, needs in vivo confirmation before clinical relevance.

Interaction of adriamycin in vitro with cardiac myofibrillar proteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interaction of adriamycin in vitro with cardiac myofibrillar proteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider