Why the study?
Does a specific intraperitoneal adriamycin dosing regimen induce progressive cardiac dysfunction while minimizing peritonitis in a rat model?
Population
75 male Wistar rats (60 adriamycin-treated, 15 control)
Comparison
Adriamycin 1 mg/kg intraperitoneally 15 times… vs Saline 10 ml/kg body wt. intraperitoneally 15…
Design
Preclinical
Follow-up
12 weeks
Authors
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Validates this adriamycin regimen for rat cardiomyopathy models without peritonitis; hypothesis-generating for human cardiotoxicity research.
Does a specific intraperitoneal adriamycin dosing regimen induce progressive cardiac dysfunction while minimizing peritonitis in a rat model?
This adriamycin administration method successfully induces a progressive cardiomyopathy model in rats while avoiding the confounding effects of peritonitis.
Teraoka et al. (2000) studied this question.
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