Why the study?
Does adriamycin induce cardiotoxicity detectable by 31P NMR in a rat model?
Population
Rat model (perfused hearts of chronically treated rats)
Comparison
Adriamycin vs Control animals
Design
Preclinical
Authors
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May support 31P NMR for anthracycline cardiotoxicity detection in rats; leaves open human translation.
Does adriamycin induce cardiotoxicity detectable by 31P NMR in a rat model?
31P NMR can detect adriamycin-induced cardiotoxicity in a rat model, as evidenced by a decreased PCr/ATP ratio that correlates with histological damage.
Dekker et al. (1991) studied this question.
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