Why the study?
Does adriamycin alter the ATP-to-PCr ratio in acute and chronic models of cardiotoxicity in rabbit hearts?
Population
Langendorff-perfused rabbit hearts
Comparison
Adriamycin vs Control animals
Design
Preclinical
Follow-up
Up to 10 weeks
Authors
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Chronic adriamycin cardiomyopathy appears independent of ATP-to-PCr changes in rabbits; hypothesis-generating for acute effects with no clinical translation yet.
Does adriamycin alter the ATP-to-PCr ratio in acute and chronic models of cardiotoxicity in rabbit hearts?
The mechanism of chronic adriamycin cardiomyopathy does not appear to be driven by progressive impairment of cellular high-energy phosphate metabolism.
Keller et al. (1986) studied this question.
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