Key result
Combined cardiac irradiation and low-dose Adriamycin in rabbits resulted in more severe myocardial lesions, pericardial effusions, and fibrosis compared to single treatments.
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Rabbits received either (a) no treatment; (b) a single radiation dose; (c) protracted low-dose Adriamycin; (d) combined cardiac irradiation and low-dose Adriamycin; or (e) protracted high-dose Adriamycin. More severe myocardial lesions (similar to those in high-dose Adriamycin groups) developed in rabbits receiving combined treatment. Pericardial effusions and fibrosis were more common in the combined treatment group.
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Eltringham et al. (1975) studied Adriamycin Cardiomyopathy. Combined cardiac irradiation and low-dose Adriamycin vs. No treatment, single radiation dose, protracted low-dose Adriamycin, or protracted high-dose Adriamycin was evaluated on Myocardial lesions, pericardial effusions, and fibrosis. Combined cardiac irradiation and low-dose Adriamycin in rabbits resulted in more severe myocardial lesions, pericardial effusions, and fibrosis compared to single treatments.
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