Key result
Intra-peritoneal instillation of bupivacaine plus buprenorphine prolonged the mean duration of post-operative analgesia compared to bupivacaine alone.
Why the study?
Post-operative pain is common after laparoscopic cholecystectomy, and bupivacaine and buprenorphine have shown promising results for analgesia.
Does intra-peritoneal bupivacaine plus buprenorphine improve the duration of post-operative analgesia compared to bupivacaine alone in patients undergoing laparoscopic cholecystectomy?
RCT (n=60)
Computer generated randomization table
No
Does intra-peritoneal bupivacaine plus buprenorphine improve the duration of post-operative analgesia compared to bupivacaine alone in patients undergoing laparoscopic cholecystectomy?
The addition of buprenorphine to intra-peritoneal bupivacaine significantly prolongs the duration of post-operative analgesia following laparoscopic cholecystectomy.
Answers are grounded in this paper and cite their sources.
Supports adding buprenorphine to intraperitoneal bupivacaine for extended post-laparoscopic cholecystectomy analgesia; extends evidence for multimodal intraperitoneal regimens.
Laparoscopic procedures are the newest techniques with better outcomes for most upper GI pathologies.As a matter of fact Laparoscopic Cholecystectomy has become the gold standard these days for cholelithiasis.In post op recovery for these patients, Post-operative pain is one of the commonest entity to deal with and there are number of drugs that can be added.Bupivacaine and Buprenorphine have shown promising results.Objective: To compare the mean duration of post-operative analgesia in laparoscopic cholecystectomy patients receiving intraperitoneal bupivacaine/bupivacaine plus buprenorphine. Study design: Randomized controlled trial.
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Akbar et al. (2023) conducted an RCT in Cholelithiasis undergoing laparoscopic cholecystectomy (n=60). Bupivacaine plus buprenorphine vs. Bupivacaine 25 ml (0.25%) was evaluated on Mean duration of post-operative analgesia (hours) (p=0.001). Intra-peritoneal instillation of bupivacaine plus buprenorphine prolonged the mean duration of post-operative analgesia compared to bupivacaine alone.
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