What question did this study set out to answer?

To evaluate the effectiveness of pre-transplant nutritional strategies in mitigating malnutrition and improving clinical outcomes in hematological patients undergoing bone marrow transplantation.

December 20, 2024NutrientsOpen Access

Nutritional Prehabilitation Intervention in Hematological Patients Undergoing Bone Marrow Transplant: A Systematic Review of the Literature

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Authors

SMStefano MancinHumanitas University EAElena AzzoliniUniversity of Siena FCFrancesco ColottaHumanitas University

Discussion

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Implication

Systematic review demonstrates reduced complications and improved survival with nutritional prehabilitation before bone marrow transplant, indicating pre-transplant feeding optimizes outcomes.

Key Points

To evaluate the effectiveness of pre-transplant nutritional strategies in mitigating malnutrition and improving clinical outcomes in hematological patients undergoing bone marrow transplantation.
Searched PubMed, CINAHL, Cochrane Library, and Embase, screening 3,545 records and including 6 studies.
Assessed study quality and risk of bias via the Joanna Briggs Institute (JBI) framework and evaluated certainty of evidence using the Oxford OCEBM system.
Nutritional prehabilitation significantly increased daily energy intake (26 vs. 24 kcal/kg/day, p = 0.038) and improved body weight maintenance (25% vs. 9%) with protein supplementation.
Interventions decreased severe acute graft-versus-host disease (17.1% vs. 43.4%, p = 0.001), pneumonia (27.6% vs. 52.7%, p = 0.002), hospital stay duration (27 vs. 32 days, p = 0.006), and parenteral nutrition requirements (53% vs. 62%, p = 0.03).
Overall survival improved among patients with ≥50% adherence to prescribed TGF-beta2 supplementation (33 vs. 25.1 months, p = 0.03).

Cite This Study

Mancin et al. (2024) studied this question.

synapsesocial.com/papers/6a95a0180d26084903f1a30d https://doi.org/10.3390/nu16244387

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Implication

Systematic review demonstrates reduced complications and improved survival with nutritional prehabilitation before bone marrow transplant, indicating pre-transplant feeding optimizes outcomes.

Nutritional Prehabilitation Intervention in Hematological Patients Undergoing Bone Marrow Transplant: A Systematic Review of the Literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Nutritional Prehabilitation Intervention in Hematological Patients Undergoing Bone Marrow Transplant: A Systematic Review of the Literature

Discussion

Member takes

Implication

Key Points

Cite This Study

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