Key result
Multimodality cardiovascular imaging plays an integral role in establishing the diagnosis, etiology, and pathophysiology of HIV-associated cardiomyopathy, which is increasingly characterized by subclinical diastolic dysfunction.
Why the study?
HIV infection causes cardiovascular complications including myocardial dysfunction, and multimodality cardiovascular imaging is essential for understanding etiology and pathogenesis as well as evaluating patients presenting with heart failure symptoms.
This review highlights the critical role of multimodality imaging in diagnosing and managing HIV-associated cardiomyopathy, emphasizing the epidemiological shift from systolic to diastolic dysfunction in the modern antiretroviral therapy era.
May inform imaging strategies in HIV cardiomyopathy; leaves open prospective validation of diastolic screening.
Despite marked advances in therapeutics, HIV infection remains a leading cause of morbidity and mortality worldwide. HIV infection is associated with cardiovascular complications including myocardial dysfunction. The description of HIV-associated cardiomyopathy (HIVAC) has evolved over time from a predominantly dilated cardiomyopathy with systolic dysfunction to one of subclinical diastolic dysfunction. Multimodality cardiovascular imaging plays an integral role in our understanding of the etiology and pathogenesis of HIVAC. Such imaging is also essential in the evaluation of individuals with chronic HIV disease who present with cardiac symptoms, especially of heart failure. In the present review, we will highlight current evidence for the role of multimodality imaging in establishing the diagnosis, etiology and pathophysiology of HIVAC as well as guiding treatment and assessing prognosis.
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Gambahaya et al. (2022) conducted a review in HIV-Associated Cardiomyopathy. Multimodality cardiovascular imaging was evaluated. Multimodality cardiovascular imaging plays an integral role in establishing the diagnosis, etiology, and pathophysiology of HIV-associated cardiomyopathy, which is increasingly characterized by subclinical diastolic dysfunction.
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