April 28, 2011The Journal of ImmunologyOpen Access

Quantitative Trait Locus Analysis, Pathway Analysis, and Consomic Mapping Show Genetic Variants of Tnni3k, Fpgt, or H28 Control Susceptibility to Viral Myocarditis

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Why the study?

Does the Vms1 locus control susceptibility to Coxsackievirus B3-mediated viral myocarditis in mice?

Population

Mouse strains (susceptible A/J, resistant B10.A, resistant C57BL/6J, and chromosome substitution strain…

Comparison

Coxsackievirus B3 infection and genetic mapping… vs Comparison between susceptible and resistant…

Design

Preclinical

Authors

SWS WiltshireVirginia Wesleyan University GLGabriel André Leiva‐TorresHéma-Québec SVSilvia M. VidalMcGill University Health Centre

Discussion

Member takes

Implication

Identifies genetic loci for CVB3 myocarditis in mice; leaves open human relevance and requires validation before any clinical consideration.

Structured PICO

Does the Vms1 locus control susceptibility to Coxsackievirus B3-mediated viral myocarditis in mice?

Population

Mouse strains (susceptible A/J, resistant B10.A, resistant C57BL/6J, and chromosome substitution strain C57BL/6J-Chr 3(A)/NaJ)

Intervention

Coxsackievirus B3 (CVB3) infection and genetic mapping of the Vms1 locus

Comparator

Comparison between susceptible and resistant mouse strains

Outcome

Susceptibility to viral myocarditis and differential gene expressionsurrogate

The Vms1 locus on chromosome 3, specifically candidate genes Fpgt, H28, and Tnni3k, controls genetic susceptibility to Coxsackievirus B3-induced viral myocarditis in mice.

Cite This Study

Wiltshire et al. (2011) studied this question.

synapsesocial.com/papers/6a95a3d7e8fca6a58c1d2058 https://doi.org/10.4049/jimmunol.1100159

Topics

Myocarditis

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Implication

Identifies genetic loci for CVB3 myocarditis in mice; leaves open human relevance and requires validation before any clinical consideration.