Key result
Dyslipidemia was independently associated with a significantly lower risk of in-hospital mortality (OR 0.113) in patients with acute STEMI undergoing primary PCI, highlighting the cholesterol paradox.
Why the study?
What are the clinical and angiographic predictors of adverse in-hospital outcomes after primary PCI in patients with acute STEMI?
Population
188 consecutive patients with acute ST-elevation myocardial infarction who underwent primary percutaneous…
Design
Cohort
Follow-up
in-hospital (median 8.95 days)
Authors
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Should not change lipid management in STEMI; leaves open confounding versus biology in the cholesterol paradox.
Cohort (n=188)
No
What are the clinical and angiographic predictors of adverse in-hospital outcomes after primary PCI in patients with acute STEMI?
Odds Ratio: 0.113 (95% CI 0.018–0.72)
Absolute Event Rate: 2% vs 22%
p-value: p=0.021
Age, Killip class, and post-procedural TIMI flow grade are independent predictors of in-hospital mortality after primary PCI for STEMI, while dyslipidemia paradoxically predicted lower mortality.
Barauskas et al. (2016) conducted a cohort in Acute ST-elevation myocardial infarction (STEMI) (n=188). Dyslipidemia vs. Normal lipid profile was evaluated on In-hospital mortality (OR 0.113, 95% CI 0.018-0.720, p=0.021). Dyslipidemia was independently associated with a significantly lower risk of in-hospital mortality (OR 0.113) in patients with acute STEMI undergoing primary PCI, highlighting the cholesterol paradox.
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