December 1, 1980Canadian Journal of Physiology and Pharmacology

Evidence against noradrenergic regulation of vasodilation in rat brown adipose tissue

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Population

Cold-acclimated rats

Comparison

Noradrenaline infusion combined with… vs Saline-infused rats

Design

Preclinical

Authors

DFDavid O. FosterUniversity of Wisconsin–Madison FDFlorent DepocasNational Academies of Sciences, Engineering, and Medicine

Discussion

Member takes

Implication

Indicates O2-dependent BAT vasodilation in rats; hypothesis-generating for local control mechanisms with no immediate clinical translation.

Structured PICO

Population

Cold-acclimated rats

Intervention

Noradrenaline (NA) infusion combined with artificially changing the concentration of O2 in arterial blood (AO2) by hemodilution, hemoconcentration, or lowering O2 in inspired air

Comparator

Saline-infused rats

Outcome

Blood flow to brown adipose tissue (QBAT) and calorigenic responsesurrogate

Vasodilation during calorigenesis in rat brown adipose tissue appears to be regulated by local O2 requirements rather than directly by noradrenaline.

Cite This Study

Foster et al. (1980) studied this question.

synapsesocial.com/papers/6a95a4ebb008990063cefa83 https://doi.org/10.1139/y80-215

View Full Paper

Ask AI

Bookmark

Implication

Indicates O2-dependent BAT vasodilation in rats; hypothesis-generating for local control mechanisms with no immediate clinical translation.

Evidence against noradrenergic regulation of vasodilation in rat brown adipose tissue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence against noradrenergic regulation of vasodilation in rat brown adipose tissue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider