Key result
Sympathetic innervation under thermoneutral conditions significantly predicted functional brown adipose tissue activation during cold stress (R2 = 0.68, P < 0.01).
Why the study?
Does mild cold exposure alter sympathetic innervation and activation of brown and white adipose tissue in lean young adults?
Population
20 adult lean normal subjects
Comparison
Exposure to mild cold (16°C) temperature vs Rest (thermoneutral conditions)
Authors
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May inform noninvasive BAT phenotyping; leaves open clinical translation pending prospective studies.
Observational (n=20)
Does mild cold exposure alter sympathetic innervation and activation of brown and white adipose tissue in lean young adults?
Effect estimate: R2 = 0.68
p-value: p=< 0.01
Sympathetic innervation levels at rest, measured by 11C-HED PET, can predict the amount of functional brown adipose tissue activated during cold stress in lean young adults.
Muzik et al. (2016) conducted an observational in Healthy lean adults (n=20). Mild cold exposure (16°C) vs. Rest (thermoneutral conditions) was evaluated on Prediction of 18F-FDG uptake during cold stress by 11C-HED retention index under thermoneutral conditions (R2 = 0.68, p=< 0.01). Sympathetic innervation under thermoneutral conditions significantly predicted functional brown adipose tissue activation during cold stress (R2 = 0.68, P < 0.01).
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