January 1, 2012Frontiers in EndocrinologyOpen Access

Assessment of Oxidative Metabolism in Brown Fat Using PET Imaging

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Why the study?

Does mild cold exposure significantly activate brown adipose tissue thermogenesis and oxidative metabolism in normal human adults?

Population

14 adult normal subjects (9 female, 5 male), mean age 30 ± 7 years.

Comparison

Exposure to mild cold evaluated via dynamic… vs Resting state, and comparison between subjects…

Design

Cohort

Authors

OMOtto MuzikWayne State College TMThomas J. MangnerRutgers, The State University of New Jersey JGJames G. GrannemanWayne State University

Discussion

Member takes

Implication

Negligible BAT contribution to energy expenditure during mild cold; challenges rodent extrapolation and leaves open therapeutic relevance in humans.

Structured PICO

Does mild cold exposure significantly activate brown adipose tissue thermogenesis and oxidative metabolism in normal human adults?

Population

14 adult normal subjects (9 female, 5 male), mean age 30 ± 7 years.

Intervention

Exposure to mild cold (16°C) evaluated via dynamic oxygen-15 (¹⁵O) PET imaging and indirect calorimetry.

Comparator

Resting state (baseline), and comparison between subjects with (BAT+) and without (BAT-) FDG tracer uptake (SUV > 2) in cervical-supraclavicular brown adipose tissue.

Outcome

Metabolic rate of oxygen (MRO₂) in brown adipose tissue and its contribution to daily energy expenditure (DEE).surrogate

Brown adipose tissue thermogenesis in humans accounts for a negligible amount of daily energy expenditure (<20 kcal/day) during moderate cold stress, suggesting that extrapolating rodent BAT metabolic data to humans is problematic.

Cite This Study

Muzik et al. (2012) studied this question.

synapsesocial.com/papers/6a8c0804a42d46e0ffcadc76 https://doi.org/10.3389/fendo.2012.00015

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January 1, 2012Frontiers in EndocrinologyOpen Access

Assessment of Oxidative Metabolism in Brown Fat Using PET Imaging

View Full Paper

Ask AI

Bookmark

Why the study?

Does mild cold exposure significantly activate brown adipose tissue thermogenesis and oxidative metabolism in normal human adults?

Population

14 adult normal subjects (9 female, 5 male), mean age 30 ± 7 years.

Comparison

Exposure to mild cold evaluated via dynamic… vs Resting state, and comparison between subjects…

Design

Cohort

Authors

OMOtto MuzikWayne State College TMThomas J. MangnerRutgers, The State University of New Jersey JGJames G. GrannemanWayne State University

Discussion

Member takes

Implication

Negligible BAT contribution to energy expenditure during mild cold; challenges rodent extrapolation and leaves open therapeutic relevance in humans.

Structured PICO

Does mild cold exposure significantly activate brown adipose tissue thermogenesis and oxidative metabolism in normal human adults?

Population

14 adult normal subjects (9 female, 5 male), mean age 30 ± 7 years.

Intervention

Exposure to mild cold (16°C) evaluated via dynamic oxygen-15 (¹⁵O) PET imaging and indirect calorimetry.

Comparator

Resting state (baseline), and comparison between subjects with (BAT+) and without (BAT-) FDG tracer uptake (SUV > 2) in cervical-supraclavicular brown adipose tissue.

Outcome

Metabolic rate of oxygen (MRO₂) in brown adipose tissue and its contribution to daily energy expenditure (DEE).surrogate

Cite This Study

Muzik et al. (2012) studied this question.

synapsesocial.com/papers/6a8c0804a42d46e0ffcadc76 https://doi.org/10.3389/fendo.2012.00015

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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