Key result
Acute cold exposure is linked to lower BAT fat fraction, inversely correlating with metabolic activity.
Why the study?
The metabolic activity of human brown adipose tissue (BAT) and its relation to temperature and fat fraction measured by proton magnetic resonance spectroscopy (1H MRS) had not been investigated in association with BAT metabolic activity determined by 18F-FDG PET.
Are temperature and fat fraction of brown adipose tissue associated with its metabolic activity in healthy subjects during cold exposure compared to room temperature?
Comparison
Acute cold exposure vs ambient room temperature
Design
Observational study using PET-MRI and 1H MRS
Authors
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1H-MRS fat fraction may enable noninvasive BAT research; leaves open validation against insulin sensitivity or lipid clearance in disease.
Observational (n=10)
Are temperature and fat fraction of brown adipose tissue associated with its metabolic activity in healthy subjects during cold exposure compared to room temperature?
1H MRS-derived temperature and fat fraction are promising noninvasive methods to study brown adipose tissue activity, which is associated with whole-body insulin sensitivity and lipid clearance.
Koskensalo et al. (2017) conducted an observational in Healthy (n=10). Acute cold exposure vs. Ambient room temperature was evaluated on Metabolic activity of brown adipose tissue, tissue temperature, and fat fraction. Acute cold exposure lowered the fat fraction of brown adipose tissue compared to room temperature, and BAT metabolic activity associated inversely with fat fraction.
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