Key result
Left atrial overload indices were significantly associated with heart failure re-admission during the first year in women with HFpEF (P=0.020), with prognostic indices differing by sex.
Why the study?
The study aimed to clarify sex-based differences in the association between left atrial overload indices and heart failure readmission in patients with HFpEF.
Do left atrial overload indices predict re-admission for heart failure differently by sex in patients with HFpEF?
Cohort (n=898)
Do left atrial overload indices predict re-admission for heart failure differently by sex in patients with HFpEF?
Answers are grounded in this paper and cite their sources.
Left atrial overload indices are prognostic for 1-year heart failure readmission in HFpEF patients, with the predictive value of specific indices varying by sex.
OBJECTIVE: We aim to clarify the differences in the association between re-admission for heart failure (HF) and left atrial (LA) overload indices by sex in heart failure and a preserved ejection fraction (HFpEF). METHODS: We analyzed 898 HFpEF patients hospitalized for acute decompensated HF. Blood tests and transthoracic echocardiography were performed before discharge. The primary endpoint was re-admission for HF during the first year. Stroke volume (SV)/LA volume (LAV), another index for LAV overload, was not a significant prognostic factor of re-admission for HF during this time. CONCLUSION: LA overload was an important prognostic factor for HF re-readmission during the first year after enrolment in patients with HFpEF, but the indices relating to LA overload differed by sex.
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Hoshida et al. (2022) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=898). Left atrial overload indices was evaluated on Re-admission for HF during the first year (p=0.020). Left atrial overload indices were significantly associated with heart failure re-admission during the first year in women with HFpEF (P=0.020), with prognostic indices differing by sex.
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