Key result
Left atrial overload indices predicted 1-year heart failure readmission in HFpEF, with diastolic to arterial elastance ratio significant in men (P=0.014) and LA volume index in women (P=0.020).
Why the study?
Sex-specific differences in the association between left atrial overload indices and heart failure readmission in HFpEF remained unclear.
Do left atrial overload indices predict 1-year heart failure readmission differently by sex in patients with HFpEF?
Cohort (n=898)
Do left atrial overload indices predict 1-year heart failure readmission differently by sex in patients with HFpEF?
Left atrial overload indices predict 1-year heart failure readmission in HFpEF patients, but the specific prognostic indices differ by sex.
Objective: We aimed to clarify the differences in the association between re-admission for heart failure (HF) and left atrial (LA) overload indices by sex in heart failure and a preserved ejection fraction (HFpEF). Methods: We analysed 898 HFpEF patients hospitalized for acute decompensated HF. Blood tests and transthoracic echocardiography were performed before discharge. The primary endpoint was re-admission for HF during the first year. Results: The ratio of diastolic elastance to arterial elastance (p=0.014), a relative index of LA pressure overload, in men and LA volume index (LAVI, p=0.020) in women were significant for re-admission for HF during the first year in the multivariable Fine-Gray analysis. Stroke volume (SV)/LA volume (LAV), another index for LAV overload, was not a significant prognostic factor of re-admission for HF during this time. Conclusion: LA overload was an important prognostic factor for HF re-readmission during the first year after enrolment in patients with HFpEF, but the indices relating to LA overload differed by sex.
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Hoshida et al. (2022) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=898). Left atrial overload indices was evaluated on Re-admission for HF during the first year (p=0.014 (men), 0.020 (women)). Left atrial overload indices predicted 1-year heart failure readmission in HFpEF, with diastolic to arterial elastance ratio significant in men (P=0.014) and LA volume index in women (P=0.020).
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