Key result
Urotensin II and its receptor mRNA expressions showed a significant positive correlation (r=0.632, p=0.001) in breast cancer tissues and were associated with menopausal status and tumor invasion.
Observational (n=59)
No
Effect estimate: r=0.632
p-value: p=0.001
Urotensin II and its receptor mRNA expressions are present in breast cancer tissues and appear associated with menopausal status and tumor invasion characteristics.
Should not change breast cancer practice; hypothesis-generating for urotensin II in tumor progression.
BACKGROUND: Urotensin II is a vasoactive polypeptide. It is known that some vasoactive polypeptides are produced and secreted by tumor cells, and act as a paracrine growth stimulant. The aim of this study was to examine the relationship between urotensin II and its receptor's messenger RNA expression in breast cancer. MATERIAL/METHODS: Fifty-nine women with breast cancer were included in this study. The median age was 48 years. The relationships between urotensin II and urotensin II receptor mRNA expressions, which were derived from fresh breast cancer tissues and adjacent normal breast tissues, and clinical and pathological parameters, were assessed. RESULTS: We found expressions of urotensin II mRNA and its receptor in 55 of 59 breast cancer tissues and in 55 of 59 normal breast tissues. We found a positive significant correlation between urotensin II and its receptor (p=0.001, r=0.632), and found a negative, but insignificant, correlation between urotensin II and age (p=0.038, r=-0.281). Urotensin II levels were higher in the premenopausal group compared to the postmenopausal group (p<0.05). The mean urotensin II receptor expression was higher in the premenopausal group (p<0.05) compared to the postmenopausal group, and its expression was also higher in the group without extra-nodal invasion compared to that of the group with extra-nodal invasion (p=0.001). Urotensin II levels were higher in the group without lymphatic invasion compared to the group with lymphatic invasion (p=0.048). CONCLUSIONS: This study is the first in the English medical literature to determine the urotensin II and its receptor mRNA expressions in breast cancer tissues. Consequently, urotensin II seems be associated with menopausal status, and extra-nodal and lymphatic invasion.
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Celaletdin Camcı (2014) conducted an observational in Breast Cancer (n=59). Urotensin II and Urotensin II receptor mRNA expression vs. Adjacent normal breast tissue and clinicopathological subgroups was evaluated on Correlation between Urotensin II and Urotensin II receptor mRNA expressions (r=0.632, p=0.001). Urotensin II and its receptor mRNA expressions showed a significant positive correlation (r=0.632, p=0.001) in breast cancer tissues and were associated with menopausal status and tumor invasion.
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