A simple method is described for the quantitative examination of small intestinal mucosal biopsies involving the determination of an index related to the surface-to-volume ratio of the mucosa. The method is of value in distinguishing minor degrees of villous abnormality and will prove useful in comparing serial changes in a given patient. It will also allow comparisons to be made between biopsies taken in different medical centres.
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Dunnill et al. (1972) studied this question.
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