Key result
Serum IL-10 levels during the early phase of foot-and-mouth disease virus infection were significantly higher in cattle that developed persistent carrier status compared to non-carriers (p=0.025).
Population
25 cattle infected with foot-and-mouth disease virus type O
Comparison
Measurement of serum IL-10 levels during the… vs Non-carrier cattle compared to carrier cattle
Design
Preclinical
Follow-up
28 days post-infection
Authors
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May identify cattle at risk for FMDV persistence; leaves open whether targeting IL-10 alters outcomes.
Observational (n=25)
p-value: p=0.025
Elevated serum IL-10 production during the early stage of foot-and-mouth disease virus infection in cattle is associated with the likelihood of developing persistent infection.
Zhang et al. (2015) conducted an observational in Foot-and-mouth disease (FMD) virus infection (n=25). Early IL-10 production (1-4 days post-infection) vs. Low or undetectable IL-10 production was evaluated on Serum IL-10 levels during early infection (1-4 days post-infection) (p=0.025). Serum IL-10 levels during the early phase of foot-and-mouth disease virus infection were significantly higher in cattle that developed persistent carrier status compared to non-carriers (p=0.025).
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